HCID 131732814, compound → HCID 86708905, compound

HRID 571358Notes

Reaction equation

HRID 571358 reaction equation
C(OC(=O)[NH:7][C@@H:8]1[CH2:19][C@H:11]2[CH2:12][N:13]([C:15](=[O:18])[NH:16][CH3:17])[CH2:14][C@@:10]2([C:20]([N:22]2[CH2:31][CH2:30][C:29]3[N:28]=[CH:27][C:26]([C:32]([F:35])([F:34])[F:33])=[CH:25][C:24]=3[CH2:23]2)=[O:21])[CH2:9]1)(C)(C)C>C(O)(C(F)(F)F)=O.C(Cl)Cl>[NH2:7][C@@H:8]1[CH2:19][C@H:11]2[CH2:12][N:13]([C:15]([NH:16][CH3:17])=[O:18])[CH2:14][C@@:10]2([C:20]([N:22]2[CH2:31][CH2:30][C:29]3[N:28]=[CH:27][C:26]([C:32]([F:35])([F:34])[F:33])=[CH:25][C:24]=3[CH2:23]2)=[O:21])[CH2:9]1

Participants

4

Reactant 1

HCID 131732814HCID 131732814, compound

Product 1

HCID 86708905HCID 86708905, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of the product from Step A (0.08 g, 0.156 mmol) in TFA (1.5 mL) and DCM (1.5 mL) was stirred at rt for 1.5 h. The volatile organic compounds were removed by evaporation, and the residue was diluted with DCM and evaporated again to give the product as a TFA salt. LC/MS: C19H24F3N5O2: m/z 412.5 (M+H).

Workup

  1. customThe volatile organic compounds were removed by evaporation
  2. additionthe residue was diluted with DCM
  3. customevaporated again

Sources & evidence

ORD record
ord-269ace6d04bd480aa1f2a93b02361da2
Source dataset
uspto-grants-2015_05
Patent number
US09024017B2

Reaction notes

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