Hydrochloric Acid → (S)-2-(methylthio)-1-phenylethanaminium chloride

HRID 571381Notes

Reaction equation

HRID 571381 reaction equation
[CH3:1][S:2][CH2:3][C@@H:4]([NH:11]C(=O)OC(C)(C)C)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[ClH:19]>O1CCOCC1>[Cl-:19].[CH3:1][S:2][CH2:3][C@H:4]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[NH3+:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 89535947HCID 89535947, compound

Product 1

HCID 89524515(S)-2-(methylthio)-1-phenylethanaminium chlorideYield 95%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

(S)-tert-butyl (2-(methylthio)-1-phenylethyl)carbamate (380 mg, 1.421 mmol) was dissolved in HCl (1066 μl, 4.26 mmol) in dioxane and allowed to stir for 30 minutes at rt. The solvents were removed in vacuo to provide (S)-2-(methylthio)-1-phenylethanaminium chloride (275 mg, 1.350 mmol, 95% yield).

Workup

  1. customThe solvents were removed in vacuo

Sources & evidence

ORD record
ord-4580b21485cc4493be5dc0375cb8b6be
Source dataset
uspto-grants-2015_05
Patent number
US09023865B2

Reaction notes

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