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HRID571407

反应详情

EQUATION

反应方程式

HRID 571407 的结构方程式

REACTANTS

反应物

5
结构：O=C(O)C(F)(F)F
HCID6422

未命名化合物

结构：O=C([O-])[O-].[Cs+].[Cs+]
HCID10796

Cesium carbonate

CCs2O3

结构：CCCCNC(N)=O
HCID11595

N-Butylurea

C5H12N2O

结构：CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21
HCID636044

1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)

C39H32OP2

结构：Clc1cc2c(cn1)c(C1CCC1)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1
HCID89525898

未命名化合物

PRODUCTS

生成物

1
结构：CCCCNC(=O)Nc1cc2[nH]nc(C3CCC3)c2cn1
HCID178449546

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CC(=O)[O-].CC(=O)[O-].[Pd+2]
催化剂HCID167845

Diacetatopalladium

C4H6O4Pd

结构：C1COCCO1
溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

In a manner similar to that described in Scheme 6 and Example 30, 6-chloro-3-cyclobutyl-1-trityl-1H-pyrazolo[4,3-c]pyridine was reacted with 1-butylurea, (Xantphos, Pd(OAc)2, Cs2CO3, dioxane, 80° C., overnight) and then deprotected with TFA to provide 1-butyl-3-(3-cyclobutyl-1H-pyrazolo[4,3-c]pyridin-6-yl)urea. MS ESI calc'd. for C15H21N5O[M+1]+ 288, found 288.