反应详情

温度

120 °C

A mixture of 6-bromonicotinaldehyde (11.2 g, 60 mmol) and CuCN (8.06 g, 90 mmol) in DMF (100 mL) was heated at 120° C. for 3 h under N2. The mixture was cooled to rt and diluted with EtOAc and filtered through a pad of celite. The organic layer was washed with water and brine and then dried (MgSO4) and concentrated. The product 5-formylpicolinonitrile (4.55 g) was obtained by silica gel chromatography (elution with 0-20% EtOAc/Hex).

1. temperatureThe mixture was cooled to rt
2. filtrationfiltered through a pad of celite
3. washThe organic layer was washed with water and brine
4. dry with materialdried (MgSO4)
5. concentrationconcentrated