Indole-5-carbonitrile → Indole

HRID 572458Notes

Reaction equation

HRID 572458 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][C:6](C#N)=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.N1C2C(=CC=CC=2)C=C1C#N>>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1

Participants

3

Reactant 2

HCID 27513Indole-5-carbonitrileHCID 37875991H-indole-2-carbonitrile

Product 1

HCID 798Indole

Procedure

The A ring indole of compounds 31 and 32 was synthesized using the same approach as 8f described in Scheme 3 above from 1H-indole-5-carbonitrile or 1H-indole-2-carbonitrile as starting material. Crude product was purified by column chromatography. Description of synthesis of compounds 31 and 32 is provided below in Example 11.

Workup

  1. customCrude product was purified by column chromatography
  2. customDescription of synthesis of compounds 31
  3. custom32 is provided below in Example 11

Sources & evidence

ORD record
ord-dc5102d6152b4e4eb62f317ab86e575b
Source dataset
uspto-grants-2015_05
Patent number
US09029408B2

Reaction notes

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