Methylamine → HCID 178483385, compound

HRID 57282Notes

Reaction equation

HRID 57282 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:14]([CH2:15][CH2:16][CH2:17]Br)=[N:13][NH:12][C:11]=1[NH2:19].[CH3:20][NH2:21]>C1COCC1>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:14]([CH2:15][CH2:16][CH2:17][NH:21][CH3:20])=[N:13][NH:12][C:11]=1[NH2:19]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 178509116HCID 178509116, compound

Product 1

HCID 178483385HCID 178483385, compoundYield 32%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 4-benzothiazol-2-yl-5-(3-bromopropyl)-2H-pyrazol-3-ylamine (130 mg, 0.39 mmol) and methylamine (5 mL of a 2 M solution in THF, 10 mmol) was stirred at room temperature for 60 hrs. The resulting solid was isolated by filtration, washed with THF, and then with water. The product was air dried to yield 38 mg (32%) of the title compound as an off white solid. MS (m/z, ES+): 288.2 (M+1, 100%).

Workup

  1. customThe resulting solid was isolated by filtration
  2. washwashed with THF
  3. customdried

Sources & evidence

ORD record
ord-a7b93501c10844e5a3d77d0eafb4e72b
Source dataset
uspto-grants-2016_09
Patent number
US09434720B2

Reaction notes

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