Methylamine → HCID 178483400, compound

HRID 57285Notes

Reaction equation

HRID 57285 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:14]([CH2:15][CH2:16][CH2:17][CH2:18]Br)=[N:13][NH:12][C:11]=1[NH2:20].[NH2:21][C:22]1NN=C(CCCCO)C=1C1SC2C=CC=CC=2N=1.CN.C1COCC1>>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:14]([CH2:15][CH2:16][CH2:17][CH2:18][NH:21][CH3:22])=[N:13][NH:12][C:11]=1[NH2:20]

Participants

5

Reactant 4

HCID 6329MethylamineHCID 8028TetrahydrofuranHCID 178509117HCID 178509117, compoundHCID 178509118HCID 178509118, compound

Product 1

HCID 178483400HCID 178483400, compound

Procedure

The title compound (30 mg) was prepared using 185 mg (0.39 mmol) of 4-benzothiazol-2-yl-5-(4-bromobutyl)-2H-pyrazol-3-ylamine, which was derived from 4-(5-amino-4-benzothiazol-2-yl-1H-pyrazol-3-yl)butan-1-ol, and 5 mL of a 2 M solution of methylamine in THF (10 mmol). MS (m/z, ES+): 302.4 (M+1, 100%).

Sources & evidence

ORD record
ord-d7ecd06b0a79405891da27005ea1ce17
Source dataset
uspto-grants-2016_09
Patent number
US09434720B2

Reaction notes

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