反应详情

To the solution of LDA (18.3 mL, 36.5 mmol) in THF (120 mL) cooled to −78° C. was added 2-methoxy-6-methylpyridine (1.5 g, 12.2 mmol) in THF (15 mL) dropwise, and then the mixture was stirred at −78 degree for 2 h. Dimethyl carbonate (1.2 mL, 14.6 mmol) was added quickly and continued to stir at −78° C. for 15 min. The reaction was quenched by H2O at −78° C. The solution was extracted with ethyl acetate, dried over sodium sulfate and evaporated under reduced pressure. The residue was purified with a standard method to give desired compound.

1. stirringto stir at −78° C. for 15 min
2. customThe reaction was quenched by H2O at −78° C
3. extractionThe solution was extracted with ethyl acetate
4. dry with materialdried over sodium sulfate
5. customevaporated under reduced pressure
6. customThe residue was purified with a standard method