Tetrabutylammonium Fluoride → HCID 86719094, compound

HRID 572914Notes

Reaction equation

HRID 572914 reaction equation
[Si]([O:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][C:16]([O:18][CH3:19])=[O:17])=[N:13][CH:14]=1)(C(C)(C)C)(C)C.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>C1COCC1>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][C:16]([O:18][CH3:19])=[O:17])=[N:13][CH:14]=1

Participants

4

Reactant 2

HCID 2724141Tetrabutylammonium FluorideHCID 86719095HCID 86719095, compound

Product 1

HCID 86719094HCID 86719094, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To the stirred solution of methyl 2-(5-((tert-butyldimethylsilyl)oxy)pyridin-2-yl)acetate (1 g, 3.5 mmol) in THF was added TBAF (1M, 3.5 ml) at room temperature. The whole mixture was stirred at room temperature overnight. It was evaporated and extracted with EtOAc, the organic layer was washed with water, evaporated and purified by a standard method.

Workup

  1. customIt was evaporated
  2. extractionextracted with EtOAc
  3. washthe organic layer was washed with water
  4. customevaporated
  5. custompurified by a standard method

Sources & evidence

ORD record
ord-e7dc8af142ad479495eb07675e6897f6
Source dataset
uspto-grants-2015_05
Patent number
US09029531B2

Reaction notes

Loading…