反应详情

To a solution of 15.00 g (63.03 mmol) of 4-fluoro-2-iodophenol (P7), Preparation 7 and 6.40 g (31.68 mmol) of 1,3-dibromopropane in 200 mL of acetone add 26.00 g (188.4 mmol) of potassium carbonate. Reflux the resulting reaction mixture for 24 hours. Cool the reaction mixture to room temperature, filter it, and concentrate the filtrate by rotary evaporation. Crystallize the resulting solid from acetonitrile to yield 12.00 g (74%) of (P8) as a white crystalline solid.

1. temperatureReflux
2. customthe resulting reaction mixture for 24 hours
3. filtrationfilter it
4. concentrationconcentrate the filtrate
5. customby rotary evaporation
6. customCrystallize the resulting solid from acetonitrile
7. customto yield 12.00 g (74%) of (P8) as a white crystalline solid