Hydrochloric Acid → HCID 67126605, compound

HRID 573072Notes

Reaction equation

HRID 573072 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].[NH2:15][CH2:16][C:17]1([NH2:23])[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1.Cl.C(N(CC)CC)C>O1CCOCC1.O>[NH2:23][C:17]1([CH2:16][NH:15][C:2]2[CH:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][C:3]=2[N+:12]([O-:14])=[O:13])[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 73244-Chloro-3-nitrobenzenesulfonamideHCID 8471TriethylamineHCID 436087274-(Aminomethyl)oxan-4-amine

Product 1

HCID 67126605HCID 67126605, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
110 °C

Procedure

A mixture of 4-chloro-3-nitrobenzenesulfonamide, 4-(aminomethyl)tetrahydro-2H-pyran-4-amine, hydrochloric acid and triethylamine in dioxane (10 mL) was heated at 110° C. overnight. After cooling, the mixture was diluted with water (10 mL), and filtered.

Workup

  1. temperatureAfter cooling
  2. filtrationfiltered

Sources & evidence

ORD record
ord-37ef2bbed1974d41ae20258cfd891311
Source dataset
uspto-grants-2015_05
Patent number
US09029404B2

Reaction notes

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