反应详情

A solution of EXAMPLE 368A (1.33 g), bis(4-methoxyphenyl)methanamine (1.046 g) and N-ethyl-N-isopropylpropan-2-amine (1.127 ml) in anhydrous 1-methyl-2-pyrrolidinone (20 mL) was stirred at 120° C. overnight. The mixture was concentrated and the residue was taken up in water (100 mL) and extracted with dichloromethane. The residue was absorbed on silica and purified by chromatography on a silica gel column, eluting with 25% ethyl acetate in hexane to provide the title compound.

1. concentrationThe mixture was concentrated
2. extractionextracted with dichloromethane
3. customThe residue was absorbed on silica
4. custompurified by chromatography on a silica gel column
5. washeluting with 25% ethyl acetate in hexane