反应详情

温度

50 °C

A mixture of 5-hydroxy-N-methoxy-N-methylpicolinamide (7.51 g), K2CO3 (6.27 g) and benzyl bromide (2.83 mL) in acetone (70 mL) was stirred at 50° C. for 14 h, evaporated, treated with water and extracted with AcOEt. The organic layer was dried over Na2SO4 and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (AcOEt/hexane) to the title compound (4.87 g).

1. customevaporated
2. additiontreated with water
3. extractionextracted with AcOEt
4. dry with materialThe organic layer was dried over Na2SO4
5. concentrationconcentrated under reduced pressure
6. customThe residue was purified by silica gel column chromatography (AcOEt/hexane) to the title compound (4.87 g)