7-Chloro-1-ethyl-1H-pyrazolo[4,3-d]pyrimidine → HCID 66727973, compound

HRID 573346Notes

Reaction equation

HRID 573346 reaction equation
Cl[C:2]1[C:3]2[N:10]([CH2:11][CH3:12])[N:9]=[CH:8][C:4]=2[N:5]=[CH:6][N:7]=1>CCOC(C)=O.[Pd]>[CH2:11]([N:10]1[C:3]2[CH:2]=[N:7][CH:6]=[N:5][C:4]=2[CH:8]=[N:9]1)[CH3:12]

Participants

4

Reactant 1

HCID 714458087-Chloro-1-ethyl-1H-pyrazolo[4,3-d]pyrimidine

Product 1

HCID 66727973HCID 66727973, compoundYield 93.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 7-chloro-1-ethyl-1H-pyrazolo[4,3-d]pyrimidine (105 mg), TEA (0.088 mL) and 10% Pd—C (30 mg) in AcOEt (5 mL) was hydrogenated under balloon pressure at room temperature for 2 h. The catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to give the title compound (80 mg).

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-82466f85a4994758adcb1ded58cd0c9f
Source dataset
uspto-grants-2015_05
Patent number
US09029536B2

Reaction notes

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