反应详情

3.00 g of phenyl 3-bromo-5-chlorophenoxycarbamate was dissolved in 50 ml of tetrahydrofuran. The resulting solution was added to a mixture of 1.54 g of cumylamine and 1.15 g of triethylamine, followed by stirring for 5 hours, while being heated to reflux. The reaction solvent was then distilled off under reduced pressure. The resulting residue was partially purified by silica gel column chromatography (eluent: hexane:ethyl acetate=3:1). The resulting crude crystal was washed with hexane to obtain 1-(3-Bromo-5-chlorophenoxy)-3-(2-phenylpropan-2-yl)urea (2.89 g, yield: 86%).

1. temperaturewhile being heated to reflux
2. distillationThe reaction solvent was then distilled off under reduced pressure
3. customThe resulting residue was partially purified by silica gel column chromatography (eluent: hexane:ethyl acetate=3:1)
4. washThe resulting crude crystal was washed with hexane