反应详情

温度

0 °C

To an ethyl acetate (30 mL) solution of 3-(3-pyridyl)propanol (1.5 g), dimethyl sulfoxide (15 mL) and triethylamine (9 mL) were added. Additionally, a pyridine sulfur trioxide complex (5.2 g) was added with stirring at 0° C. for 2 hours as it was. The reaction mixture was concentrated under reduced pressure, and purified by silica gel column chromatography (hexane:ethyl acetate=30:70→0:100) to obtain a titled compound (1:1 g) having the following physical property values.

1. additionAdditionally, a pyridine sulfur trioxide complex (5.2 g) was added
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. custompurified by silica gel column chromatography (hexane:ethyl acetate=30:70→0:100)