Water → HCID 51110142, compound

HRID 573531Notes

Reaction equation

HRID 573531 reaction equation
[O:1]([CH2:8][CH2:9][CH2:10]Br)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:12]1([N:18]2[C:22]([SH:23])=[N:21][N:20]=[N:19]2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C(=O)([O-])[O-].[K+].[K+].O>CC(C)=O.C(OCC)(=O)C>[O:1]([CH2:8][CH2:9][CH2:10][S:23][C:22]1[N:18]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:19]=[N:20][N:21]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

7

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 68522Benzene, (3-bromopropoxy)-HCID 1785279861-phenyltetrazole-5-thiol

Product 1

HCID 51110142HCID 51110142, compoundYield 100.4%

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 8857Ethyl AcetateSolvent

Procedure

3-phenoxypropyl bromide (1.53 g) was dissolved in acetone (9 mL), 1-phenyl-5-mercapto-1H-tetrazole (1.27 g) and potassium carbonate (985 mg) were added, and the mixture was stirred at room temperature for 3 hours. To the reaction solution, water was added, and the extract obtained by extraction with ethyl acetate was washed with water and a saturated saline; dried with anhydrous magnesium sulfate; and concentrated under reduced pressure to obtain a titled compound (2.23 g) having the following physical property values.

Workup

  1. washwas washed with water
  2. dry with materialdried with anhydrous magnesium sulfate
  3. concentrationand concentrated under reduced pressure

Sources & evidence

ORD record
ord-d64297cc292b4653a841a3624c3d9cf8
Source dataset
uspto-grants-2015_05
Patent number
US09029574B2

Reaction notes

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