Trifluoroacetic acid → HCID 68380820, compound

HRID 573627Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C:19]3[C:18]([NH2:20])=[CH:17][C:16]([CH3:21])=[N:15][C:14]=3[S:13][CH:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[CH3:22][N:23]1[CH:27]=[C:26]([S:28](Cl)(=[O:30])=[O:29])[N:25]=[CH:24]1.[C:32]([OH:38])([C:34]([F:37])([F:36])[F:35])=[O:33]>>[F:35][C:34]([F:37])([F:36])[C:32]([OH:38])=[O:33].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C:19]3[C:14](=[N:15][C:16]([CH3:21])=[CH:17][C:18]=3[NH:20][S:28]([C:26]3[N:25]=[CH:24][N:23]([CH3:22])[CH:27]=3)(=[O:30])=[O:29])[S:13][CH:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

Reactant 3

HCID 6422Trifluoroacetic acid

HCID 27368871-methyl-1H-imidazole-4-sulfonyl chloride

HCID 68324020HCID 68324020, compound

Product 1

HCID 68380820HCID 68380820, compound

Procedure

Following general method outlined in Example 1, starting from 3-[3,4-bis(methyloxy)phenyl]-6-methylthieno[2,3-b]pyridin-4-amine (62 mg, 0.150 mmol) (Description 24) and 1-methyl-1H-imidazole-4-sulfonyl chloride (54.0 mg, 0.299 mmol), the title compound (26 mg) was isolated as a TFA salt. LCMS (B) m/z: 445 [M+1]+, Rt 2.41 min.

Sources & evidence

ORD record: ord-d11807b429a24cbfa418b271a43ccaf5
Source dataset: uspto-grants-2015_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09029545B2

Reaction notes

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