反应详情

4 g of pyridinylpyridazinone 7 dissolved in an excess (40 ml) of phosphorus oxychloride are refluxed for 8 hours. After cooling, the reaction mixture is poured into 250 ml of ice-cold water and then neutralized, dropwise, with a saturated aqueous solution of NaHCO3. After extraction with dichloromethane (5×100 ml), the organic phase is dried over MgSO4 and then concentrated under reduced pressure, to give the chlorinated pyridazine 8a with a yield of 95%.

1. temperatureare refluxed for 8 hours
2. temperatureAfter cooling
3. extractionAfter extraction with dichloromethane (5×100 ml)
4. dry with materialthe organic phase is dried over MgSO4
5. concentrationconcentrated under reduced pressure