反应详情

3,3,3-Trifluoro-2-hydroxy-2-methylpropanoic acid (0.6 g, 3.80 mmol) was dissolved in MeCN (5 ml). DIPEA (0.663 ml, 3.80 mmol) was added and stirred for 5 min. Benzyl bromide (541 mg, 3.16 mmol) was added and the reaction mixture was stirred at RT for 16 h followed by 70° C. for 16 h. After cooling to RT, the solvent was removed in vacuo and the resulting residue was dissolved in DCM. The mixture was washed with water and the organic portion was separated by means of a phase separator. The solvent was removed in vacuo to afford the title compound.

1. stirringthe reaction mixture was stirred at RT for 16 h
2. waitfollowed by 70° C. for 16 h
3. customthe solvent was removed in vacuo
4. dissolutionthe resulting residue was dissolved in DCM
5. washThe mixture was washed with water
6. customthe organic portion was separated by means of a phase separator
7. customThe solvent was removed in vacuo