Hydrazine, (4-chlorophenyl)-, hydrochloride (1:1) → 8-chloro-2,3,4,5-tetrahydro-2-methyl-5-(3-(pyrrolidin-1-yl)propyl)-1H-pyrido[4,3-b]indole

HRID 574459Notes

Reaction equation

HRID 574459 reaction equation
Br[CH2:2][CH2:3][CH2:4][N:5]1[CH2:9][CH2:8][CH2:7][CH2:6]1.Cl.[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([NH:18]N)=[CH:14][CH:13]=1.[CH3:20][N:21]1[CH2:26][CH2:25][C:24](=O)[CH2:23][CH2:22]1>C(N(CC)CC)C>[Cl:11][C:12]1[CH:17]=[CH:16][C:15]2[N:18]([CH2:2][CH2:3][CH2:4][N:5]3[CH2:9][CH2:8][CH2:7][CH2:6]3)[C:24]3[CH2:25][CH2:26][N:21]([CH3:20])[CH2:22][C:23]=3[C:14]=2[CH:13]=1

Participants

5

Reactant 3

HCID 71600Hydrazine, (4-chlorophenyl)-, hydrochloride (1:1)HCID 740491-Methyl-4-piperidoneHCID 130340441-(3-Bromopropyl)pyrrolidine

Product 1

HCID 578759488-chloro-2,3,4,5-tetrahydro-2-methyl-5-(3-(pyrrolidin-1-yl)propyl)-1H-pyrido[4,3-b]indole

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The title compound is prepared by following Method 8 by using 1-(3-bromopropyl)pyrrolidine, 4-chlorophenylhydrazine hydrochloride, triethylamine and N-methyl-4-piperidone

Sources & evidence

ORD record
ord-a6762ace96424a50938045d608bbe82f
Source dataset
uspto-grants-2015_05
Patent number
US09034880B2

Reaction notes

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