Triethylamine → HCID 178514732, compound

HRID 574786Notes

Reaction equation

HRID 574786 reaction equation
FC(F)(F)C(O)=O.FC(F)(F)C(O)=O.[O:15]1[CH2:20][CH2:19][N:18]([C@@H:21]2[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]2)[CH2:17][CH2:16]1.F[C:29]1[CH:34]=[CH:33][C:32]([S:35]([NH2:38])(=[O:37])=[O:36])=[CH:31][C:30]=1[N+:39]([O-:41])=[O:40].C(N(CC)CC)C>O1CCCC1>[O:15]1[CH2:16][CH2:17][N:18]([C@@H:21]2[CH2:22][CH2:23][C@H:24]([NH:27][C:29]3[CH:34]=[CH:33][C:32]([S:35]([NH2:38])(=[O:37])=[O:36])=[CH:31][C:30]=3[N+:39]([O-:41])=[O:40])[CH2:25][CH2:26]2)[CH2:19][CH2:20]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 167824874-Fluoro-3-nitrobenzenesulfonamideHCID 178511581HCID 178511581, compound

Product 1

HCID 178514732HCID 178514732, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of EXAMPLE 39B (0.40 g), 4-fluoro-3-nitrobenzenesulfonamide (0.478 g) and triethylamine (2 mL) in tetrahydrofuran (10 mL) was stirred for 3 days at room temperature. The reaction mixture was concentrated and purified by flash chromatography (silica gel, 0-30% methanol/dichloromethane) providing the product.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. custompurified by flash chromatography (silica gel, 0-30% methanol/dichloromethane)
  3. customproviding the product

Sources & evidence

ORD record
ord-e325dd34712145d7bf4f830b7c36fcc9
Source dataset
uspto-grants-2015_05
Patent number
US09034875B2

Reaction notes

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