反应详情

A solution of 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine (164 mg, 0.75 mmol), 1-bromo-2-(2-bromoethoxy)ethane (418 mg, 1.8 mmol), and DIPEA (0.64 mL, 3.6 mmol) in THF (2 mL) was stirred at reflux overnight. The mixture was concentrated, diluted with water, and extracted with EtOAc. The combined extracts were dried over Na2SO4, filtered, and concentrated. The residue was purified by preparative thin-layer chromatography to give the title compound. MS (m/z): 290 (M+H)+.

1. temperatureat reflux overnight
2. concentrationThe mixture was concentrated
3. additiondiluted with water
4. extractionextracted with EtOAc
5. dry with materialThe combined extracts were dried over Na2SO4
6. filtrationfiltered
7. concentrationconcentrated
8. customThe residue was purified by preparative thin-layer chromatography