反应详情

温度

100 °C

The mixture of 2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (474 mg, 2 mmol), K2CO3 (828 mg, 6 mmol), and MeI (710 mg, 5 mmol) in DMF (10 mL), was stirred at 100° C. overnight. Then it was cooled and extracted by EA/H2O, the organic layer was combined, washed by brine, dried over anhydrous Na2SO4, and concentrated to give the crude compound in 93% yield. MS (m/z): 266 (M+H)+.

1. temperatureThen it was cooled
2. extractionextracted by EA/H2O
3. washwashed by brine
4. dry with materialdried over anhydrous Na2SO4
5. concentrationconcentrated