(R)-tert-butyl 3-ureidopyrrolidine-1-carboxylate → (R)-1-(pyrrolidin-3-yl)urea

HRID 57542Notes

Reaction equation

HRID 57542 reaction equation
[NH:1]([C@@H:5]1[CH2:9][CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6]1)[C:2]([NH2:4])=[O:3]>Cl>[NH:7]1[CH2:8][CH2:9][C@@H:5]([NH:1][C:2]([NH2:4])=[O:3])[CH2:6]1

Participants

3

Reactant 1

HCID 71113416(R)-tert-butyl 3-ureidopyrrolidine-1-carboxylate

Product 1

HCID 59286189(R)-1-(pyrrolidin-3-yl)urea

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

(R)-tert-butyl 3-ureidopyrrolidine-1-carboxylate from step A was treated with HCl solution (in EtOAc, 30 mL) for 2 hours. The mixture was concentrated in vacuo to give the crude title compound. MS (m/z): 130 (M+H)+.

Workup

  1. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-3adef84ce87b4695bba69b0c8b6f8979
Source dataset
uspto-grants-2016_09
Patent number
US09434726B2

Reaction notes

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