反应详情

温度

80 °C

To a solution of N-(piperidin-4-yl)acetamide (341 mg, 2.4 mmol) in DMF (15 mL) was added K2CO3 (331 mg, 2.4 mmol) and 1-fluoro-4-nitrobenzene (282 mg, 2 mmol) at room temperature. The reaction was stirred at 80° C. for 24 hours. After that, the reaction was poured into 50 mL of water and extracted with EA (3×25 mL), washed with H2O (25 mL) and brine (25 mL), dried over Na2SO4 and concentrated to give yellow solid. MS (m/z): 264 (M+H)+

1. extractionextracted with EA (3×25 mL)
2. washwashed with H2O (25 mL) and brine (25 mL)
3. dry with materialdried over Na2SO4
4. concentrationconcentrated
5. customto give yellow solid