反应详情

温度

20 °C

To a solution of N-(1-(4-nitrophenyl)piperidin-4-yl)acetamide (568 mg, 2 mmol) in THF (15 mL) was added NaH (60%, 200 mg, 5 mmol) at room temperature. The reaction was stirred at 20° C. for 15 minutes. After that, iodomethane (300 mg, 4 mmol) was dropped into the reaction and stirred at 60° C. for 18 hours. The reaction was treated with sat. NH4Cl solution and extracted with n-BuOH, washed with brine, dried over Na2SO4 and concentrated to give yellow solid. MS (m/z): 278 (M+H)+

1. stirringstirred at 60° C. for 18 hours
2. extractionextracted with n-BuOH
3. washwashed with brine
4. dry with materialdried over Na2SO4
5. concentrationconcentrated
6. customto give yellow solid