反应详情

温度

80 °C

To a solution of tert-butyl piperazine-1-carboxylate (1120 mg, 6 mmol) in DMF (25 mL) was added K2CO3 (828 mg, 6 mmol) and 1,2-difluoro-4-nitrobenzene (795 mg, 5 mmol) at room temperature. The reaction was stirred at 80° C. for 24 hours. After that, the reaction was poured into 50 mL of water and extracted with EA (3×25 mL), washed with H2O (25 mL) and brine (25 mL), dried over Na2SO4 and concentrated to give yellow solid. MS (m/z): 226 (M−99)+

1. extractionextracted with EA (3×25 mL)
2. washwashed with H2O (25 mL) and brine (25 mL)
3. dry with materialdried over Na2SO4
4. concentrationconcentrated
5. customto give yellow solid