反应详情

温度

50 °C

To the title compound of step 1 (300 mg, 1.7 mmol) in CH3CN (15 mL) was added K2CO3 (726 mg, 5.2 mmol) at 25° C. under N2. After stirring for 30 min, benzyl bromide (450 mg, 2.6 mmol) was added, and the mixture was heated at 50° C. for 20 h. Following CH2Cl2 extractive work up, the residue was triturated with PE:EA (3:1) to give the title compound (250 mg, 54%) as a yellow solid. 1H NMR: (CDCl3, 400 MHz) δ: 7.43-7.29 (m, 6H), 6.12 (d, J=7.2 Hz, 1H), 5.27 (s, 2H), 3.57 (s, 3H). LCMS: 261.0 (M+1)+

1. customFollowing CH2Cl2 extractive work up, the residue was triturated with PE