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HRID575776

反应详情

EQUATION

反应方程式

HRID 575776 的结构方程式

REACTANTS

反应物

4
结构：CCOC(C)=O
HCID8857

Ethyl acetate

C4H8O2

结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：CCB(O)O
HCID521157

Ethylboronic acid

C2H7BO2

结构：CS(=O)(=O)c1ccc(Br)c([N+](=O)[O-])c1
HCID2060366

2-Bromo-5-methylsulfonylnitrobenzene

C7H6BrNO4S

PRODUCTS

生成物

1
结构：CCc1ccc(S(C)(=O)=O)cc1[N+](=O)[O-]
HCID58266121

未命名化合物

收率 41.1%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：Cl[Pd]Cl.[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1
催化剂HCID178418228

未命名化合物

结构：C1COCCO1.O
溶剂HCID21886435

1,4-Dioxane--water (1/1)

C4H10O3

PROCEDURE

实验过程

bromo-4-methylsulfonyl-2-nitrobenzene (2 g, 7.0 mmol), ethylboronic acid (0.57 g, 7.7 mmol), K2CO3 (3.0 g, 21 mmol), Pd(dppf)Cl2 (0.29 g, 0.35 mmol) in 1,4-dioxane/water (4:1) (24 mL) were heated at 85° C. under N2 overnight. Silica gel chromatography (PE:EA=6:1) gave the title compound (0.66 g, 40%) as a brown solid.