6-((Dibenzylamino)methyl)morpholin-3-one → 6-(Aminomethyl)morpholin-3-one

HRID 57599Notes

Reaction equation

HRID 57599 reaction equation
C([N:8]([CH2:16][CH:17]1[CH2:22][NH:21][C:20](=[O:23])[CH2:19][O:18]1)CC1C=CC=CC=1)C1C=CC=CC=1>CCO.[OH-].[OH-].[Pd+2]>[NH2:8][CH2:16][CH:17]1[CH2:22][NH:21][C:20](=[O:23])[CH2:19][O:18]1

Participants

4

Reactant 1

HCID 99955506-((Dibenzylamino)methyl)morpholin-3-one

Product 1

HCID 100575426-(Aminomethyl)morpholin-3-one

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolvent

Procedure

A solution of 6-((dibenzylamino)methyl)morpholin-3-one (340 mg, 1.09 mmol), Pd(OH)2/C (170 mg) in EtOH (30 mL) was stirred equipped under H2 balloon overnight. The solution was filtered and concentrated to give white oil. The crude product was used directly for next step without purification.

Workup

  1. customequipped under H2 balloon overnight
  2. filtrationThe solution was filtered
  3. concentrationconcentrated
  4. customto give white oil
  5. customThe crude product was used directly for next step without purification

Sources & evidence

ORD record
ord-bbc83b480d1644d2811adaf60dc45bb8
Source dataset
uspto-grants-2016_09
Patent number
US09434726B2

Reaction notes

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