Tetrahydrofuran → HCID 89375853, compound

HRID 575999Notes

Reaction equation

HRID 575999 reaction equation
[O:1]1[CH:3]([CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]#[N:12])[CH:2]1[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]#[N:21].C1C[O:25]CC1>O.C(Cl)Cl>[OH:25][CH:2]([CH:3]([OH:1])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]#[N:12])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]#[N:21]

Participants

5

Reactant 2

HCID 8028TetrahydrofuranHCID 89375877HCID 89375877, compound

Product 1

HCID 89375853HCID 89375853, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6344DichloromethaneSolvent

Procedure

To a solution of 0.10 g like-8,8′-(oxirane-2,3-diyl)dioctanenitrile in 5.0 g THF was added 0.50 mL of a solution of 0.0988 g 70% HClO4 in 1.9104 g water. After standing for 24 h at room temperature, the mixture was diluted with 250 mL CH2Cl2, which resulted in the separation of aqueous droplets. The mixture was dried over Na2CO3 and evaporated to afford 0.10 g of product as a white powder.

Workup

  1. customresulted in the separation of aqueous droplets
  2. dry with materialThe mixture was dried over Na2CO3
  3. customevaporated

Sources & evidence

ORD record
ord-e516f599f2e1415c9a30aa1b3ff18fb5
Source dataset
uspto-grants-2015_05
Patent number
US09035078B2

Reaction notes

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