Benzaldehyde → HCID 68160102, compound

HRID 576000Notes

Reaction equation

HRID 576000 reaction equation
[CH:1](=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:9][CH2:10]O[Si](OCC)(OCC)CCCN.[C:23]([CH2:25][C:26]([O:28]CC)=O)#[N:24]>CN(C)C=O>[C:2]1([CH:1]=[C:25]([C:26](=[O:28])[CH2:9][CH3:10])[C:23]#[N:24])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 240BenzaldehydeHCID 7764Ethyl cyanoacetateHCID 13521(3-Aminopropyl)triethoxysilane

Product 1

HCID 68160102HCID 68160102, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Benzaldehyde (2 mmol, 0.2 ml) and 0.05 g of LDH/APTES were stirred in 5 ml of dimethylformamide for 5 min. Then the active methylene compound i.e. ethyl cyanoacetate (2 mmol, 0.226 ml) was added and stirring was continued till 90 min at 27° C. The catalyst was filtered and the product was extracted with ethyl acetate, dried over anhydrous sodium sulfate. The final product (FIG. 2) was confirmed by Gas chromatography to afford the product (3-phenyl-2-propanoyl-prop-2-ene-nitrile) in 98% yield.

Workup

  1. filtrationThe catalyst was filtered
  2. extractionthe product was extracted with ethyl acetate
  3. dry with materialdried over anhydrous sodium sulfate

Sources & evidence

ORD record
ord-b1f44d388e304826816d174c97d868c0
Source dataset
uspto-grants-2015_05
Patent number
US09035086B2

Reaction notes

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