Hydrochloric Acid → (9H-fluoren-9-yl)methyl hexahydropyrrolo[3,4-b]pyrrole-1 (2H)-carboxylate hydrochloric acid

HRID 57605Notes

Reaction equation

HRID 57605 reaction equation
[N:1]1([C:16]([O:18][CH2:19][CH:20]2[C:32]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[C:26]3[C:21]2=[CH:22][CH:23]=[CH:24][CH:25]=3)=[O:17])[CH2:5][CH2:4][CH:3]2[CH2:6][N:7](C(OC(C)(C)C)=O)[CH2:8][CH:2]12.[ClH:33]>CO>[ClH:33].[N:1]1([C:16]([O:18][CH2:19][CH:20]2[C:32]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[C:26]3[C:21]2=[CH:22][CH:23]=[CH:24][CH:25]=3)=[O:17])[CH2:5][CH2:4][CH:3]2[CH2:6][NH:7][CH2:8][CH:2]12

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 711137921-(9H-fluoren-9-yl)methyl 5-tert-butyl hexahydropyrrolo[3,4-b]pyrrole-1,5-dicarboxylate

Product 1

HCID 86717379(9H-fluoren-9-yl)methyl hexahydropyrrolo[3,4-b]pyrrole-1 (2H)-carboxylate hydrochloric acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1-(9H-fluoren-9-yl)methyl 5-tert-butyl hexahydropyrrolo[3,4-b]pyrrole-1,5-dicarboxylate (810 mg, 1.86 mmol) was treated with HCl in MeOH (5 mL) for 2 hours and then concentrated in vacuo to afford the title compound.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-4da18fe442634f1a8fa28fa1fc033ed0
Source dataset
uspto-grants-2016_09
Patent number
US09434726B2

Reaction notes

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