反应详情

A solution of methyl 3-aminopropanoate hydrochloride (4.88 mmol), Et3N (6.50 mmol) and 5,7-dichloropyrido[4,3-b]pyrazine (3.25 mmol) in THF (10 mL) was stirred at room temperature overnight. Volatiles were removed under reduced pressure, and the residue was treated with water and extracted with EtOAc. The combined extracts were dried over Na2SO4, filtered, and concentrated. The residue was purified by chromatography to afford the title compound. MS (m/z): 267 (M+H)+.

1. customVolatiles were removed under reduced pressure
2. additionthe residue was treated with water
3. extractionextracted with EtOAc
4. dry with materialThe combined extracts were dried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated
7. customThe residue was purified by chromatography