Potassium Carbonate → HCID 53380482, compound

HRID 576432Notes

Reaction equation

HRID 576432 reaction equation
C([O:4][C@H:5]1[C@H:10]([O:11]C(=O)C)[C@@H:9]([O:15]C(=O)C)[C@H:8]([C:19]2[CH:20]=[C:21]3[C:25](=[CH:26][CH:27]=2)[CH2:24][O:23][CH:22]3[C:28]2[CH:33]=[CH:32][C:31]([CH2:34][CH3:35])=[CH:30][CH:29]=2)[O:7][C@@H:6]1[CH2:36][O:37]C(=O)C)(=O)C.C([O-])([O-])=O.[K+].[K+]>CO>[CH2:34]([C:31]1[CH:32]=[CH:33][C:28]([CH:22]2[C:21]3[C:25](=[CH:26][CH:27]=[C:19]([C@H:8]4[C@H:9]([OH:15])[C@@H:10]([OH:11])[C@H:5]([OH:4])[C@@H:6]([CH2:36][OH:37])[O:7]4)[CH:20]=3)[CH2:24][O:23]2)=[CH:29][CH:30]=1)[CH3:35]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 71110697HCID 71110697, compound

Product 1

HCID 53380482HCID 53380482, compoundYield 55.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of 151 (380 mg, 0.68 mmol) in CH3OH (5.0 mL) was added K2CO3 (65 mg, 0.47 mmol) at room temperature. After 1.5 h, the resulting mixture was filtered, and then purified by preparative HPLC (reverse phase) to provide the title compound (145 mg, 55%) as an off-white solid.

Workup

  1. filtrationthe resulting mixture was filtered
  2. custompurified by preparative HPLC (reverse phase)

Sources & evidence

ORD record
ord-6b6830bb1e9449b194f1bd093b253c58
Source dataset
uspto-grants-2015_05
Patent number
US09034921B2

Reaction notes

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