N-Acetyl-Neuraminic Acid → N-acetyl-neuraminic acid Sodium Salt

HRID 576486Notes

Reaction equation

HRID 576486 reaction equation
[C:1]([NH:4][C@H:5]1[C@H:14]([C@@H:15]([C@@H:17]([CH2:19][OH:20])[OH:18])[OH:16])[O:13][C:8]([OH:12])([C:9](=[O:11])[OH:10])[CH2:7][C@@H:6]1[OH:21])(=[O:3])[CH3:2].C([O-])(O)=O.[Na+:26]>O>[Na+:26].[C:1]([NH:4][C@H:5]1[C@H:14]([C@@H:15]([C@@H:17]([CH2:19][OH:20])[OH:18])[OH:16])[O:13][C:8]([OH:12])([C:9](=[O:10])[O-:11])[CH2:7][C@@H:6]1[OH:21])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 439197N-Acetyl-Neuraminic AcidHCID 516892Sodium Bicarbonate

Product 1

HCID 23662668N-acetyl-neuraminic acid Sodium SaltYield 102.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

N-acetylneuraminic acid (1 g, 3.23 mmol) was dissolved in water (20 ml), then stirred with NaHCO3 (0.26 g, 3.09 mmol to PH 6˜6.5), after freeze-dried to afford the title product as white powder (1.05 g, 98%).

Workup

  1. customafter freeze-dried

Sources & evidence

ORD record
ord-e678c09ccf824373bfc999cd5d04914e
Source dataset
uspto-grants-2015_05
Patent number
US09040503B2

Reaction notes

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