反应详情

A 250 mL flask was charged with tetralone (4 g, 27.4 mmol) and benzaldehyde (3.88 g, 36.6 mmol). This was dissolved in warm tetrahydrofuran (15 mL), and to this yellow solution was slowly added a 4 wt % solution of KOH in methanol (125 mL). The reaction was stirred for 4 days at room temperature. The solvent was then removed under reduced pressure, and it was poured into 150 mL of water and extracted with methylene chloride. The organic extract was dried over magnesium sulfate and filtered, and the solvent was removed at reduced pressure to afford 4.1 g (64%) as white powder.

1. customThe solvent was then removed under reduced pressure, and it
2. additionwas poured into 150 mL of water
3. extractionextracted with methylene chloride
4. extractionThe organic extract
5. dry with materialwas dried over magnesium sulfate
6. filtrationfiltered
7. customthe solvent was removed at reduced pressure
8. customto afford 4.1 g (64%) as white powder