Ammonium Hydroxide → HCID 89717258, compound

HRID 57728Notes

Reaction equation

HRID 57728 reaction equation
C[O:2][C:3]([C:5]1[N:6]([NH:10][C:11](=[O:22])[CH:12]([O:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH3:13])[CH:7]=[N:8][CH:9]=1)=O.[OH-].[NH4+:24]>>[CH2:15]([O:14][CH:12]([CH3:13])[C:11]([NH:10][N:6]1[C:5]([C:3]([NH2:24])=[O:2])=[CH:9][N:8]=[CH:7]1)=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 897151953-(2-Benzyloxy-propionylamino)-3H-imidazole-4-carboxylic acid methyl ester

Product 1

HCID 89717258HCID 89717258, compoundYield 100%

Conditions

Temperature
60 °C

Procedure

Compound 9 (8.2 g, 27 mmol) and ammonium hydroxide (100 mL) were mixed and heated to 60° C. for two hours. The reaction mixture was concentrated in vacuo to give compound 10 (7.8 g, 100% yield) as white solid. LC-MS: m/z 289 [M+H]+.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-fdb8cfbb4f554818b646057d5349b883
Source dataset
uspto-grants-2016_09
Patent number
US09434733B2

Reaction notes

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