3-Bromopyridine → HCID 86706425, compound

HRID 577432Notes

Reaction equation

[NH2:1][C@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[NH:8][C:9]1[N:10]=[N:11][C:12]([C:22]([NH2:24])=[O:23])=[C:13]([NH:15]C2C=NC=CC=2)[N:14]=1.Cl[C:26]1[CH:31]=[CH:30][N:29]=[C:28]2[N:32]([CH3:35])[CH:33]=[CH:34][C:27]=12.BrC1C=NC=CC=1>>[NH2:1][C@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[NH:8][C:9]1[N:10]=[N:11][C:12]([C:22]([NH2:24])=[O:23])=[C:13]([NH:15][C:26]2[CH:31]=[CH:30][N:29]=[C:28]3[N:32]([CH3:35])[CH:33]=[CH:34][C:27]=23)[N:14]=1

Participants

Reactant 3

HCID 122863-Bromopyridine

HCID 126460404-Chloro-1-methyl-1H-pyrrolo[2,3-b]pyridine

HCID 72705803HCID 72705803, compound

Product 1

HCID 86706425HCID 86706425, compound

Procedure

The title compound was prepared in the same procedure as described in Example 3-(((1R,2S)-2-aminocyclohexyl)amino)-5-(pyridin-3-ylamino)-1,2,4-triazine-6-carboxamide. Here, 4-chloro-1-methyl-1H-pyrrolo[2,3-b]pyridine was utilized as the coupling partner instead of 3-bromopyridine. MS found for C18H23N9O as (M+H)+ 382.4. UV: λ=213, 263 nm. Proton NMR: (CD3OD) δ 8.78 (1H, br), 8.28 (1H, br) 7.46 (1H, d, J=3.6 Hz), 6.76 (1H, m), 4.82 (1H, m), 3.93 (3H, s), 3.73 (1H, br), 2.01-1.60 (8H, m) ppm.

Sources & evidence

ORD record: ord-7ffbce7dcf5142ba91c6892199cf4366
Source dataset: uspto-grants-2015_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09040530B2

Reaction notes

Loading…