反应详情

A solution of 4-chloro-1H-pyridazin-6-one (6.000 mmol; 783.2 mg), Iodomethane (7.200 mmol; 1032 mg; 0.453 mL), and potassium carbonate (9.000 mmol; 1256 mg) in DMF (12 mL) was stirred at room temperature overnight. The mixture was filtered. The filtrate was partitioned between EtOAc and water. The organic layer was concentrated. The residue was purified on silica eluted with 0 to 40% EtOAc in DCM to afford 5-chloro-2-methyl-pyridazin-3-one as an off-white solid (514.7, 59%).

1. filtrationThe mixture was filtered
2. customThe filtrate was partitioned between EtOAc and water
3. concentrationThe organic layer was concentrated
4. customThe residue was purified on silica
5. washeluted with 0 to 40% EtOAc in DCM