反应详情

温度

120 °C

A mixture of 2,6-dibromopyrazine (5.0198 mmol; 1194.1 mg), tert-butyl 1,4-diazepane-1-carboxylate (5.271 mmol; 1055.6 mg), and triethylamine (15.06 mmol; 1539 mg; 2.12 mL) in IPA (10 mL) in a sealed pressure vial was heated at 120° C. overnight. The mixture was cooled to room temperature, and then concentrated. The residue was purified on silica elute with 0 to 100% EtOAc in Heptane to afford tert-butyl 4-(6-bromopyrazin-2-yl)-1,4-diazepane-1-carboxylate (1.6965 g, 95%). MS (ESI) m/z: 357 [M+H]+

1. temperatureThe mixture was cooled to room temperature
2. concentrationconcentrated
3. customThe residue was purified on silica
4. washelute with 0 to 100% EtOAc in Heptane