Trifluoroacetic acid → HCID 53482764, compound

HRID 578725Notes

Reaction equation

HRID 578725 reaction equation
FC(F)(F)C(O)=O.[CH2:8]([C:23]([CH2:49][O:50][CH2:51][CH2:52][O:53][CH2:54][CH2:55][O:56][CH2:57][CH2:58][O:59][CH2:60][CH2:61][O:62][CH3:63])([CH2:39][O:40][CH2:41][C:42]([O:44]C(C)(C)C)=[O:43])[CH2:24][O:25][CH2:26][CH2:27][O:28][CH2:29][CH2:30][O:31][CH2:32][CH2:33][O:34][CH2:35][CH2:36][O:37][CH3:38])[O:9][CH2:10][CH2:11][O:12][CH2:13][CH2:14][O:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][O:21][CH3:22]>ClCCl>[CH2:24]([C:23]([CH2:49][O:50][CH2:51][CH2:52][O:53][CH2:54][CH2:55][O:56][CH2:57][CH2:58][O:59][CH2:60][CH2:61][O:62][CH3:63])([CH2:39][O:40][CH2:41][C:42]([OH:44])=[O:43])[CH2:8][O:9][CH2:10][CH2:11][O:12][CH2:13][CH2:14][O:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][O:21][CH3:22])[O:25][CH2:26][CH2:27][O:28][CH2:29][CH2:30][O:31][CH2:32][CH2:33][O:34][CH2:35][CH2:36][O:37][CH3:38]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 53482763HCID 53482763, compound

Product 1

HCID 53482764HCID 53482764, compoundYield 96.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoroacetic acid (TFA, 0.5 ml) and dichloromethane (0.5 ml) was added to 20 mg of 5. The mixture was shaken at room temperature for 1 h and the volatile materials was then removed at reduced pressure to give 18 mg of 6 as a yellow oil.

Workup

  1. customthe volatile materials was then removed at reduced pressure

Sources & evidence

ORD record
ord-eb95f250a61747419efdaa224febe94d
Source dataset
uspto-grants-2015_05
Patent number
US09040637B2

Reaction notes

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