Water → HCID 58021967, compound

HRID 578814Notes

Reaction equation

HRID 578814 reaction equation
[CH3:1][O:2][C:3]([C:5]1[S:6][CH:7]=[C:8]2[C:13]=1[C:12](=[O:14])[N:11]([C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([S:21][CH:22]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH3:23])[CH:16]=1)[C:10](=[O:30])[NH:9]2)=[O:4].O.C(=O)([O-])[OH:33].[Na+].OOS([O-])=O.[K+]>CC(C)=O>[CH3:1][O:2][C:3]([C:5]1[S:6][CH:7]=[C:8]2[C:13]=1[C:12](=[O:14])[N:11]([C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([S:21]([CH:22]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH3:23])=[O:33])[CH:16]=1)[C:10](=[O:30])[NH:9]2)=[O:4]

Participants

6

Reactant 4

HCID 962WaterHCID 516892Sodium BicarbonateHCID 23707502Potassium hydroxy sulfiteHCID 68992898HCID 68992898, compound

Product 1

HCID 58021967HCID 58021967, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a solution of 5-methoxycarbonyl-3-[3-(1-phenyl -ethylthio)phenyl]thieno[3,4-d]pyrimidine-2,4(1H,3H)-dione (50 mg) in acetone (3 mL)-water (0.6 mL) were added sodium hydrogen carbonate (24 mg) and OXONE (registered trademark) (84 mg), and the mixture was stirred at room temperature for 30 minutes. The reaction mixture was extracted with ethyl acetate, and the extract was washed with 1 mol/L hydrochloric acid, water and brine successively, and dried over anhydrous magnesium sulfate.

Workup

  1. extractionThe reaction mixture was extracted with ethyl acetate
  2. washthe extract was washed with 1 mol/L hydrochloric acid, water and brine successively
  3. dry with materialdried over anhydrous magnesium sulfate

Sources & evidence

ORD record
ord-0232f9d7b1294c41be0d59d85b5a0bf3
Source dataset
uspto-grants-2015_05
Patent number
US09040693B2

Reaction notes

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