反应详情

温度

110 °C

A solution containing 2-bromo-6-chloro-3-methylpyridine (487 mg, 2.24 mmol), tert-butyl N-[(3S)-6-oxo-3-piperidyl]carbamate (400 mg, 1.87 mmol), Copper(I) iodide (356 mg, 1.87 mmol), Potassium carbonate (310 mg, 2.24 mmol) and N,N′-Dimethylethylenediamine (329 mg, 3.73 mmol) in dioxane 12 mL was stirred at 110° C. 18 h. The reaction was filtered through celite and concentrated. The crude product was purified by flash chromatography (EtOAc/Heptane eluted at 50% EtOAc) to give the desired product 350 mg 38% yield. MS (ESI) m/z: 340.1.

1. custom18 h
2. filtrationThe reaction was filtered through celite
3. concentrationconcentrated
4. customThe crude product was purified by flash chromatography (EtOAc/Heptane eluted at 50% EtOAc)