Methanol → Lactic Acid

HRID 579415Notes

Reaction equation

HRID 579415 reaction equation
O.O.Cl[Sn]Cl.[NH4+].[Cl-].CO.C(O)[C@H:11]1[O:16][C@H:15]([O:17][C@]2(CO)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@H:14]([OH:29])[C@@H:13](O)[C@@H]1O>O>[C:15]([O:16][CH3:11])(=[O:17])[CH:14]([CH3:13])[OH:29].[C:15]([OH:17])(=[O:16])[CH:14]([CH3:13])[OH:29]

Participants

7

Reactant 4

HCID 887MethanolHCID 5988Sucrose2×HCID 25517Ammonium ChlorideHCID 61436Stannous chloride dihydrate

Product 2

HCID 612Lactic AcidHCID 11040Methyl Lactate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
130 °C

Procedure

In the reaction, 100 g of SnCl2.2H2O and 200 g of NH4Cl were added into a reactor (inside volume 10.0 L) as catalyst. 3.0 kg of methanol was also added into the reactor. The reactor was sealed and heated to 130° C. under stirring. A solution of 0.500 kg sucrose in 0.800 kg water was pumped into the reactor with a flow of 10.0 mL/min to carry out the reaction. After pumping all of the sucrose solution into the reactor, the reaction was kept running for another 1.5 h to complete the reaction. The resulted solution was analyzed by GC and high-performance liquid chromatography (HPLC). 80.2% of total molar yield of methyl lactate and lactic acid was obtained. The reaction was reproduced and a total yield of methyl lactate and lactic acid of 95.0% was obtained.

Workup

  1. additionwere added into a reactor (inside volume 10.0 L) as catalyst
  2. customThe reactor was sealed
  3. customthe reaction
  4. customthe reaction

Sources & evidence

ORD record
ord-47d55d9a19b84200adfd7dbd080d4a0b
Source dataset
uspto-grants-2015_05
Patent number
US09040739B2

Reaction notes

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