Hydrochloric Acid → HCID 86683396, compound

HRID 579426Notes

Reaction equation

HRID 579426 reaction equation
C(OC([N:8]1[CH2:17][CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:20]C)[C:14]=2[CH:18]=[O:19])[CH2:9]1)=O)(C)(C)C.[ClH:22]>C(OCC)(=O)C>[ClH:22].[OH:20][C:13]1[CH:12]=[CH:11][C:10]2[CH2:9][NH:8][CH2:17][CH2:16][C:15]=2[C:14]=1[CH:18]=[O:19]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86683398HCID 86683398, compound

Product 1

HCID 86683396HCID 86683396, compoundYield 93.4%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To 5-formyl-6-methoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester (1.41 g, 4.84 mmol) in ethyl acetate (1.0 mL), a 3.3 M solution of anhydrous HCl in ethyl acetate was added and the mixture was stirred at room temperature for 2 h. The precipitated product was collected, washed with ethyl acetate and dried in air. In this manner the title compound (1.03 g, 4.52 mmol, 93.4%) was obtained as a white powder.

Workup

  1. customThe precipitated product was collected
  2. washwashed with ethyl acetate
  3. customdried in air

Sources & evidence

ORD record
ord-c5ae5dc63eba42319cbc2210ae6bd707
Source dataset
uspto-grants-2015_05
Patent number
US09040714B2

Reaction notes

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