HRID579536

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：CC(=O)NC(CCCCB1OC(C)(C)C(C)(C)O1)(CCC1Cc2ccccc2CN1C(=O)OC(C)(C)C)C(=O)NC(C)(C)C

HCID66833409

未命名化合物

PRODUCTS

生成物

结构：CC(=O)NC(CCCCB1OC(C)(C)C(C)(C)O1)(CCC1Cc2ccccc2CN1)C(=O)NC(C)(C)C

HCID66833703

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8857

Ethyl acetate

C4H8O2

2 次

PROCEDURE

实验过程

A solution of tert-butyl 3-(3-acetamido-3-(tert-butylcarbamoyl)-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)heptyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate in ethyl acetate was treated with a solution of HCl (g) in ethyl acetate (approximately 2 M). After stirring for 30 min the reaction was concentrated to dryness and the crude hydrochloride product was used without further purification.

WORKUP

后处理

concentrationwas concentrated to dryness
customthe crude hydrochloride product was used without further purification

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e1cc7bd7acb54984902755d39568f990
来源数据集: uspto-grants-2015_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09040703B2
来源说明: uspto-grants-2015_05

反应 SMILES

[C:1]([NH:4][C:5]([C:38](=[O:44])[NH:39][C:40]([CH3:43])([CH3:42])[CH3:41])([CH2:25][CH2:26][CH2:27][CH2:28][B:29]1[O:33][C:32]([CH3:35])([CH3:34])[C:31]([CH3:37])([CH3:36])[O:30]1)[CH2:6][CH2:7][CH:8]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:10][N:9]1C(OC(C)(C)C)=O)(=[O:3])[CH3:2].Cl>C(OCC)(=O)C>[C:1]([NH:4][C:5]([CH2:6][CH2:7][CH:8]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:10][NH:9]1)([CH2:25][CH2:26][CH2:27][CH2:28][B:29]1[O:30][C:31]([CH3:36])([CH3:37])[C:32]([CH3:34])([CH3:35])[O:33]1)[C:38]([NH:39][C:40]([CH3:41])([CH3:42])[CH3:43])=[O:44])(=[O:3])[CH3:2]