Benzenesulfonyl chloride → N-(prop-2-yn-1-yl)benzenesulfonamide

HRID 579697Notes

Reaction equation

[C:1]1([S:7](Cl)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:11]([NH2:14])[C:12]#[CH:13]>>[CH2:11]([NH:14][S:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)(=[O:9])=[O:8])[C:12]#[CH:13]

Participants

Reactant 2

HCID 7369Benzenesulfonyl chloride

HCID 239041Propargylamine

Product 1

HCID 11287036N-(prop-2-yn-1-yl)benzenesulfonamide

Procedure

A benzenesulfonyl chloride derivative of the general formula (2) is reacted with propargylamine to obtain an N-propargylbenzenesulfonamide derivative of the general formula (4). A compound of the general formula (4) is reacted with 2-trifluoromethylbenzoyl halide to synthesize a compound of the general formula (1).

Sources & evidence

ORD record: ord-5ea7c4146fe44b4c9299f1461e4f377a
Source dataset: uspto-grants-1988_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04749407

Reaction notes

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