Isopropanol → HCID 19857591, compound

HRID 579817Notes

Reaction equation

HRID 579817 reaction equation
[CH:1]1([NH:7][OH:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:9]1O[CH:10]1[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.C([OH:21])(C)C>>[CH:1]1([N:7]([CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[OH:21])[OH:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 3776IsopropanolHCID 7276Styrene OxideHCID 72935Cyclohexylhydroxylamine

Product 1

HCID 19857591HCID 19857591, compoundYield 33%

Procedure

A solution of 2.14 g of N-cyclohexylhydroxylamine and 2.23 of styrene oxide in 50 ml of isopropanol is heated at 45° C. for 3 hours and under reflux for 20 hours. The reaction mixture is concentrated under reduced pressure and the residue is purified by liquid chromatography to afford the title compound in a 33% yield as a yellow oil.

Workup

  1. temperatureunder reflux for 20 hours
  2. concentrationThe reaction mixture is concentrated under reduced pressure
  3. customthe residue is purified by liquid chromatography

Sources & evidence

ORD record
ord-cf7d7d01cc62430a8c05ef28cebe7cf1
Source dataset
uspto-grants-1988_06
Patent number
US04749733

Reaction notes

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